Son of Benjamin Harrison, of "Berkeley," and brother of Benjamin Harrison, the signer of the Declaration of Independence, was born about 1727, attended William and Mary College, resided at Clifton, Cumberland county; was chairman of the county committee of safety, and on April 22, 1776, drafted and submitted to the people assembled at Cumberland Court House, the first explicit instructions in favor of independence adopted by a public meeting in any of the colonies. He was later a member of the house of delegates under the new constitution of Virginia. He married Susannah, daughter of Isham Randolph, of Dungenness. He was ancestor of Carter Henry Harrison, mayor of Chicago in 1893. He died in 1793-94.